Marijuana Tied To Better Blood Sugar Control

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People who had used marijuana in the past month had smaller waists and lower levels of insulin resistance – a diabetes precursor – than those who never tried the drug, in a new study.

The findings, based on surveys and blood tests of about 4,700 U.S. adults, aren’t enough to prove marijuana keeps users thin or wards off disease. And among current pot smokers, higher amounts of marijuana use weren’t linked to any added health benefits, researchers reported in The American Journal of Medicine.

“These are preliminary findings,” said Dr. Murray Mittleman, who worked on the study at Beth Israel Deaconess Medical Center in Boston.

“It looks like there may be some favorable effects on blood sugar control, however a lot more needs to be done to have definitive answers on the risks and potential benefits of marijuana usage.”

Although pot smoking is a well-known cause of “the munchies,” some previous studies have found marijuana users tend to weigh less than other people, and one suggested they have a lower rate of diabetes. Trials in mice and rats hint that cannabis and cannabinoid receptors may influence metabolism.

The new study used data from a national health survey conducted in 2005-2010. Researchers asked people about drug and alcohol use, as well as other aspects of their health and lifestyle, and measured their insulin and blood sugar levels.

Just under 2,000 participants said they had used marijuana at some point, but not recently. Another 600 or so were current users – meaning they had smoked or otherwise consumed the drug in the past month.

Compared to people who had never used pot, current smokers had smaller waists: 36.9 inches versus 38.3 inches, on average. Current users also had a lower body mass index – a ratio of weight to height – than never-users.

When other health and lifestyle measures were taken into account, recent pot use was linked to 17 percent lower insulin resistance, indicating better blood sugar control, and slightly higher HDL (“good”) cholesterol levels.

However, there was no difference in blood pressure or blood fats based on marijuana use, Mittleman’s team found.

A Causal Link?

Mittleman said that in his mind, it’s still “preliminary” to say marijuana is likely to be responsible for any diabetes-related health benefits.

“It’s possible that people who choose to smoke marijuana have other characteristics that differ (from non-marijuana smokers),” and those characteristics are what ultimately affect blood sugar and waist size, he told Reuters Health.

Dr. Stephen Sidney from the Kaiser Permanente Division of Research in Oakland, California, said he wonders if cigarette smoking may partially explain the association. Marijuana users are also more likely to smoke tobacco, he told Reuters Health.

“People who use tobacco oftentimes tend to be thinner,” said Sidney, who has studied marijuana use and weight but didn’t participate in the new study. “So I really wonder about that.”

Another limitation with this and other studies, Sidney and Mittleman agreed, is that all of the data were collected at the same time, so it’s unclear whether marijuana smoking or changes in waist size and blood sugar came first.

“The question is, is the marijuana leading to the lower rate (of diabetes) or do they have something in common?” said Dr. Theodore Friedman, who has studied that issue at Charles R. Drew University of Medicine and Science in Los Angeles.

He and his colleagues think the link is probably causal. “But it’s really hard to prove that,” Friedman, who also wasn’t involved in the new research, told Reuters Health.

One possibility is that the anti-inflammatory properties of marijuana help ward off diabetes, he said. But he agreed that more research is needed to draw out that link.

“I want to make it clear – I’m not advocating marijuana use to prevent diabetes,” Friedman said. “It’s only an association.”

SOURCE: http://bit.ly/10Ty3La — The American Journal of Medicine, online May 16, 2013.

Source: Reuters (Wire)
Author: Genevra Pittman
Published: May 23, 2013
Copyright: 2013 Thomson Reuters

Marijuana studies under Trudeau shelved before results Analyzed

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Ralph Miller was barely 30 years when he was hand-picked to lead a Canadian commission on whether marijuana should be legalized.

As research director, it was his job to guide a small army of scientists to investigate the nonmedicinal impact of a much-demonized drug during the late 1960s and early 1970s.

On May 29, 1969, then-prime minister Pierre Elliott Trudeau appointed Gerald Le Dain, a former dean of Osgoode Hall Law School and a future Supreme Court justice, to lead the inquiry. Le Dain hired the Miller — one of the few scientists who had a foot in both academia and the alternative culture. He was working at McMaster University at the time and had come to Canada a few years earlier from his native Detroit.

It has been described as one of the most comprehensive royal commissions ever conducted. The inquiry lasted almost four years. Nearly 30 public hearings took place across the country. Miller’s group oversaw 120 projects examining the physiological, psychological and behavioural effects of marijuana and other illegal drugs. They looked at extent and patterns of use, the social context of these drugs, how they played in mass media, legal and illegal sources of distribution, their role in law enforcement and the correctional system, among other things.

Around the same time, research funded by Ontario’s Conservative government was underway in Toronto to study the long-term effects of marijuana smoking in male and female volunteers. Dr. C.G. (Bill) Miles’ series of studies for the Addiction Research Foundation fed into the commission’s work though only portions of the results from the male studies were ever published.

By the time the commission issued its last of four reports in 1973, the perceived “drug crisis” in Canada was already waning. The commissioners were divided on whether pot should be legalized or decriminalized and much of the innovative research was left unanalyzed, according to Miller. The material was packed into boxes bound for the national archives. Miller says he would be willing to advise keen graduate students on how to start unpacking some of that rich data.

the Toronto Star spoke with Miller by email at an ashram in Rishikesh, India, and later by phone in West Vancouver, B.C., where he still consults on the impact of marijuana as well and holistic psychology.

“I have gotten a lot of mileage (kilometerage?) out of my Le Dain cannabis research,” he quipped by email.

Here is an edited transcript of his remarks on the collision of marijuana, science and politics from that time.

What prompted the commission?

“There was a lot of talk that drugs were destroying our youth, that hospitals were full of young people gone crazy on the use of drugs and that crime had gone up from drugs.

That was the crisis that caused Trudeau to say what is going on here.

All it was originally going to be was a departmental inquiry about marijuana issues. And then of course concern about LSD, psychedelics and so on.

At that point, coke hadn’t really reared its head in Canada much and heroin was entirely restricted to the West Coast.

Their great mistake, the Cabinet’s, is that they didn’t specifically exclude anything. They didn’t consider alcohol and tobacco to be drugs because in the general population it isn’t.

I made a point on logical grounds and in terms of physiological and socioeconomic effects, we had to include alcohol.

So the interim report did include alcohol, but not tobacco.

But I wrote all the tobacco stuff and stuffed it in the final report with only general approval at the end because they didn’t want to tackle that as well.

But when you look at the alcohol and drug research, it makes everything else a bad joke.

That’s why I quit working in the area.

They weren’t interested in the problem, in terms of the socio-economic impact of drugs, which means alcohol and tobacco. Added up, everything else is nothing compared to alcohol and tobacco problems.”

How did you land the job?

“They couldn’t find anyone in Canada qualified who also had a foot in the alternative culture.

I had given a talk on the non-medical use of drugs as part of a university conference. Le Dain heard about that and called me personally at McMaster to meet with him.

At that time, I had a giant Afro (dark brown, black) and had recently escaped from the U.S. to McMaster.

I purposely didn’t spiff myself up.

Le Dain himself was a conservative man, but brilliant, funny and intellectually honest.

I thought this was going to be just another government blah, blah, blah and I wasn’t really interested.

In my interview he never mentioned my hair.

Now my hair is trimmed up. I have my vice-president Biden hairdo on now.

No one else had ever been paid to work full time in these areas. Not only doing the original research, but surveying anyone who had ever done any LSD or any cannabis research. No one else had ever been in a position to do this before.

I was easily the world expert in cannabis.

What were some of the highlights of your research?

There were some amazing and funny things.

We got permission to use the RCMP airport at Rockcliffe. We wanted to see how fast stoners could drive around, what they would run over, if they could park.

That’s where the first driving studies were done.

We tested marijuana and alcohol on runways they weren’t using at the time.

We had regular stoners rating as high as they ever got and still driving around in the RCMP airport.

We did the first and only survey of every RCMP officer, went through all of their chemical analysis records in detail. And three months later, we had the meeting with the RCMP officers.

They were very embarrassed because they were expected to have all this data on marijuana and crime.

Other than busting people for simple possession and small dealers, they had nothing, except some guys who got busted for marijuana and were already under suspicion for gang rape a few weeks earlier. There was one case of a young man who turned out to be schizophrenic. He had taken hash and assaulted his parents. But it wasn’t clear it was even in the same month.

They said they were sure the world literature would support them, which it didn’t.

So that blew away the marijuana-causing-crime issue.

The LSD crimes were a young man naked worshipping the golden boy statue in front of the capitol building in Manitoba; some guys naked running through Stanley Park; and three people caught inappropriately dressed worshipping the trees in the park.

One of the crimes was he pulled into a gas station while high on LSD and tried to get them to service six imaginary automobiles. How’s that for heavy crime?

The worst one of all? A woman was caught attempting to fornicate with a peanut-vending machine.

The RCMP officers writing this down must have had a hoot but the head commissioners didn’t think this was funny at all. They were highly embarrassed.

We surveyed every psychiatric hospital and every hospital and major clinic with a psychiatric ward or outpatient clinic.

Physicians were seeing these kids coming in seeming schizy and that they were smoking dope and assumed that the families will want to blame something outside. Because it’s either the parenting or the outside. Because genetics is very hidden and not clearly known at that time.

In Ottawa, study, No difference between number of schizophrenics to be expected (1-3 per cent of population in age groups) and number being reported as being caused by marijuana/LSD. Which means marijuana or LSD was not likely causing anything but was maybe concomitant in increasing the symptoms.

The psych hospitals were full of people with alcohol problems. Again, alcohol wiped everything else off the map.

Was the drug crisis exaggerated?

“A general but not well-defined fear fed into “drug crisis.”

Many believed marijuana was a gateway drug. But in those days, few people smoked marijuana who didn’t start with tobacco.

I just gave a talk on that in India.”

Where did the pot for your research come from?

“A field run by the U.S. government in Kentucky. They collected seeds from around the world and were growing them in different conditions there.

Kentucky pot was a dark, rich green.”

What happened?

“We ran out of money and all of the studies we did — the pharmacology studies — were left only in the not-finished, final statistical analysis.

They didn’t come up with the money for a follow-up until all of my staff members had jobs elsewhere.

That was in 1973/74.

All of our core research, even the data, is in the national archives. Most is still in microfiche. And most of it hasn’t been published other than in the reports. Except the stuff that we involved outside people who had their own research grants from universities in California and around Ontario that published on their own.

But I couldn’t do it free.

I had my two kids. No access to staff or computers.

I was living in a wonderful commune in Stanley Park, Vancouver. I worked at a rehab program.

When the commission was over, Trudeau put the word out to the prosecutors and the whole judicial system and police to not waste time on simple possession.

Trudeau couldn’t do much with it. There wasn’t the political will around the country. They were still very conservative about it.

And here we are, a half-century later just about, and now the issue is coming around again. It’s about time.

I’ve been disappointed that no one seems to be tracking down any of us about the political, socio-economic issues.

Even young Trudeau himself seems to be dealing with these issues and doesn’t mention his dad’s commission at all.

He’s fishing around for answers and his dad’s commission did the work. And people don’t even seem to recognize it.”

What was your final conclusion?

“The big plague of stoners bringing Canada to its knees is a farce.”

Source: Toronto Star Newspapers Ltd.
Link: http://www.thestar.com/news/canada/2013/04/08/governments_research_on_marijuanas_effects_done_long_ago.html
Author:Diana Zlomislic

Weird 1972 Experiment In Marijuana Use

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marijuana_grow_1In the winter of 1972, 20 young women took part in one of the weirdest scientific experiments in this country’s history.

For 98 days in a downtown Toronto hospital, their brains, hearts, kidneys, livers, blood and urine were rigorously tested and analyzed.  A team of nurses kept round-the-clock records of their behaviour, logged at half-hour intervals.

Just how was marijuana affecting the 10 who had to smoke it every day?

Forty-one years later, these women are still wondering what exactly happened to them during their three-month stretch as human guinea pigs.

Doreen Brown, who now lives in Cambridge, is one of the women who took part in the study while in her 20s.  She turns 63 this month.

In the late 1960s, Brown moved to downtown Toronto to live on her own after her mother died.  She was 17.

“I was full of grief, a brick wall,” says Brown.  “I did things I knew weren’t good for me.”

Acid, mescaline, marijuana.

Though high or tired, she never missed a shift as a department store secretary.

But by the time she was 21, the lifestyle was wearing on her.  When a co-worker told her a group of scientists was looking for female volunteers to participate in a marijuana study for money, she saw an escape.

“It was a very split-second decision,” Brown says.  “I didn’t like what I was doing.  I wanted a change and thought, ‘Why not?’ ”

The research was part of a million-dollar program, the last in a series of provincially funded experiments designed to answer one of the country’s most pressing questions, raised when then-prime minister Pierre Trudeau entertained the idea of legalizing marijuana.

The study was lead by C.G.  ( Bill ) Miles, a British psychologist working in Toronto.

In 1971, the Addiction Research Foundation opened a research and treatment hospital where Miles’ marijuana study, Project E206, would be held.

He assembled a team that included two behavioural psychologists, one doctor, a psychiatrist, a social worker and a full-shift complement of registered nurses and attendants.

The hospital welcomed the 20 women to the ward with a formal dinner on Jan.  31, 1972.

Brown, then 21, scanned the long table.  None of the women, aged 18 to 35, looked familiar, though some seemed to know each other.

The ward was clean and modern, with blue carpet underfoot and the smell of fresh paint in the air.

It seemed an ideal place for a personal reinvention.

“I was hoping that maybe in there I would solve some of my issues – to be more open, happier,” Brown says.  “I was definitely a lost soul at that point.  Directionless.  I needed help but I didn’t know where to go to get it.”

The women were quickly split into two groups in two different areas of the hospital.  Half of them – the experimental group – were required to smoke increasingly potent doses of marijuana twice a night, while the other half – the control group – did not.  Both sides could buy as many relatively mild joints as they wanted for 50 cents apiece at a store that also sold alcohol, junk food, toiletries, cigarettes and magazines.

And then they got to work.

A key element of the study was its microeconomy.  The women were required to cover the cost of their existence, except for their bed and water, for 98 days.  Whatever money they earned and did not spend on food, clothing or entertainment, they could keep.  A $250 bonus awaited those who stuck with the experiment until the end.  Those who quit early would lose the extra payout and up to 75 per cent of their savings.

They made their living on a primitive-looking wooden device, a Guatemalan backstrap loom, on which they wove colourful, fuzzy, woollen belts with knotted tassels.  For every belt that passed inspection – it had to contain at least two colours and measure 132 centimetres in length – the women received $2.50.

After a few days of practice, the task got easier.

One participant bought chalk from the ward store to draw murals on the lounge walls.  Another, a professional bartender, mixed drinks.  Women in both groups were known to walk around naked.  Living on locked, separate wards didn’t stop women from the two groups from communicating with each other or people in surrounding office buildings – like the men who were being held in the forensic psychiatry unit at the Clarke Institute, which was next door.  The women wrote friendly, short messages on large placards and flashed their signs through the large windows that faced the street and an interior courtyard.

The carefree vibe didn’t last long.

The joints became so potent that some sought a doctor’s note to get out of their nightly obligations, saying they felt too sick to smoke.

“We were asking them to take it away,” Brown says.  “They knew we wanted it taken away; there was no doubt.  I felt comatose.  I couldn’t do anything.

“It became torture,” Brown says.

In the last week, the women who were left on the mandatory smoking unit refused to continue.

On May 8, 1972, the women left the centre.

Brown expected relief, some sense of freedom, but she felt paranoid instead.

“It was very scary,” she says.  “I thought, ‘Where am I going to go? What am I going to do?’ I was afraid to get on the subway.

“I was hoping that being in there for those 98 days might give me some perspective.  But if anything, for me, it magnified my problems.”

She spent a few years in therapy and went to the University of Toronto to study political science and history.

In her late 30s, she got pregnant and moved to Cambridge to raise her son.  She still works full-time at a local hearing clinic.  She has a granddaughter.

She still wonders what became of the results of the experiment.

Brown says she made several inquiries during the ’80s and ’90s.  She would have been more aggressive but feared she might lose her job at the time if word got out that she had taken part in a marijuana experiment.

She’s less concerned now.

“I want to know, I want to know,” she says.  “The dosages.  What they found psychologically, physically.  I feel ripped off, taken advantage of.  It’s just like it didn’t happen.  I feel like, yeah, you gave three months of your life for what?

“Were the results that horrible that they didn’t give them to us? You wonder.  I think they might have supported legalizing marijuana.  That’s why they didn’t come out.  I don’t know.  It leaves you with a lot of questions.”

Miles died in 2009 at the age of 74, but there are still some people who can help fill in the blanks of the women-and-marijuana study.

Janet McDougall was one of the junior researchers on the project.

She recalls the group disbanding suddenly and being left virtually alone with a few binders and reels of brown data tape.  On Miles’ instructions, she sent portions of it to economists at Texas A&M University.

Among them was John Kagel, now a professor of applied microeconomics at Ohio State University.  “Our analysis showed these people were perfectly rational, worked their butts off.  There was a beautiful, inadvertent event where they went on strike because they were making them smoke too much marijuana and it was interfering with their earnings, which appeared to be a primary motivation for some of them going into the thing.”

Research today indicates that while frequent cannabis smoking may well have harmful effects – including dependence and susceptibility to lung infections – motivation is not a problem.

Junior researcher McDougall does not know where the rest of the research data is today.

Dr.  Harold Kalant, the renowned former director of biological and behavioural research at the Addiction Research Foundation who, at 90, still works for its successor, the Centre for Addiction and Mental Health, knew in general terms what Miles was doing and what he found.

Did politics get in the way of Miles disseminating the data into a final report?

“My guess is that it probably wasn’t yielding anything that was going to have a direct influence on policy,” says Kalant.

For all the questions it raised, the study did answer at least one question convincingly, according to Ohio State’s Kagel.

“In terms of the central issue, if you legalize marijuana, were you going to get a bunch of stoned people just hanging out smoking dope all the time and not doing any work? This is fairly convincing evidence that wasn’t going to happen.”

Source: Record, The (Kitchener, CN ON)
Copyright: 2013 Metroland Media Group Ltd.
Contact: [email protected]
Website: http://news.therecord.com/
Author: Diana Zlomislic