Image from page 585 of “American journal of pharmacy” (1835)
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Identifier: americanjourna911919phil
Title: American journal of pharmacy
Year: 1835 (1830s)
Authors: Philadelphia College of Pharmacy Philadelphia College of Pharmacy and Science
Subjects: Pharmacy Pharmacology
Publisher: Philadelphia : Philadelphia College of Pharmacy
Contributing Library: Smithsonian Libraries
Digitizing Sponsor: Smithsonian Libraries
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and hypnotic action. Of the three actions mentioned, the hypnotic effect presenteditself as the most likely means of physiologic standardization. * Read before the meeting of the Pennsylvania Pharmaceutical Associa-tion, Buena Vista Springs, June 26, 1919. 1 Ott, Isaac: Therapeutic Gazette, 1883, supplement to March number,pages 12 to 17 inc. 2 Nagle, A. C.: Druggists Circular, Feb., 1881, p. 18. 576 Standardisation of Piscidia erythrina. {AmsJe°putr^grm The similarity between the actions of Jamaica dogwood andcannabis suggested the possibility of employing similar methods ofstandardization. A fluid extract of the drug was accordingly administered in cap-sules to dogs and found to produce incoordination and ataxia similarto that produced by cannabis. The hypnotic effect of Jamaica dogwood, however, was found tobe less than that of cannabis, as it required approximately 17 timesas much Jamaica dogwood to produce the same degree of inco-ordination in dogs as that produced by cannabis.
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Fig. 1. Normal Dog. For standardization purposes the end reaction to be observed isone just sufficient to produce muscular incoordination in a dog. The details of the method employed follow: Animals.—Short-haired dogs of medium size (6 to 12 Kilos)are well adapted for this work. They show the different stages ofthe drugs action because of their comparative high cerebral de-velopment. Animals for assay purposes should be selected with great care,it being necessary to pick out those that are healthy, intelligent,quiet, and which have shown by previous tests that they are easilysusceptible to the action of the drug. After several dogs have been selected, the operator, before usingthem for actual work, should study each animal in order to familiar- Am Sept 1^19™ } Standardization of Piscidia erythrina. 577 ize himself with the behavior, peculiarities, etc., of the dog undernormal conditions. The same animal may be used many times,provided that twenty-four to thirty-six hours are allow
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